Having tried others, this is the highest and most effective, pain reduction, swelling and joint issues reduced 3 days without and I feel it. Be aware, this will stain orange so handle with extreme care, wash your hands. I use with pepper, cinnamon and ginger in coffee with olive oil (per research, the most effective combo for activity) without the "C" it really does not work. the capsules from others just don't work -- get the powder!!